Self-Destruct is learned by 21 species by level, 78 by machine, 48 by tutor and 6 by egg

Effect, in PokéAPI's words

“User faints.”

Who learns it

91 species in all, 8 of 25 games shown

Scarlet and Violet: 16 species

Species	Method	Level
Forretress	Level up	1
Pineco	Level up	6
Minior	Level up	22
Geodude	Level up	24
Graveler	Level up	24
Golem	Level up	24
Voltorb	Level up	26
Electrode	Level up	26
Koffing	Level up	28
Weezing	Level up	28
Drifloon	Level up	29
Glimmet	Level up	29
Glimmora	Level up	29
Drifblim	Level up	31
Qwilfish	Egg
Varoom	Egg

Legends Arceus: 7 species

Species	Method	Level
Geodude	Level up	47
Graveler	Level up	47
Golem	Level up	47
Drifloon	Level up	47
Drifblim	Level up	47
Azelf	Level up	57
Overqwil	Level up	57

Brilliant Diamond and Shining Pearl: 16 species

Species	Method	Level
Forretress	Level up	1, 6
Pineco	Level up	6
Geodude	Level up	24
Graveler	Level up	24
Golem	Level up	24
Voltorb	Level up	26
Electrode	Level up	26
Koffing	Level up	28
Weezing	Level up	28
Drifloon	Level up	29
Drifblim	Level up	31
Baltoy	Level up	33
Claydol	Level up	33
Sudowoodo	Egg
Bonsly	Egg
Munchlax	Egg

Sword and Shield: 71 species

Species	Method	Level
Koffing	Level up, Machine	28
Weezing	Level up, Machine	28
Drifloon	Level up, Machine	29
Ferroseed	Level up, Machine	30
Ferrothorn	Level up, Machine	30
Drifblim	Level up, Machine	31
Baltoy	Level up, Machine	33
Claydol	Level up, Machine	33
Genesect	Level up, Machine	91
Jigglypuff	Machine
Wigglytuff	Machine
Shellder	Machine
Cloyster	Machine
Gastly	Machine
Haunter	Machine
Gengar	Machine
Onix	Machine
Exeggcute	Machine
Exeggutor	Machine
Snorlax	Machine
Mewtwo	Machine
Mew	Machine
Sudowoodo	Machine
Steelix	Machine
Qwilfish	Machine
Corsola	Machine
Seedot	Machine
Nuzleaf	Machine
Shiftry	Machine
Wailmer	Machine
Wailord	Machine
Torkoal	Machine
Lunatone	Machine
Solrock	Machine
Glalie	Machine
Metang	Machine
Metagross	Machine
Regirock	Machine
Regice	Machine
Registeel	Machine
Bonsly	Machine
Munchlax	Machine
Magnezone	Machine
Lickilicky	Machine
Azelf	Machine
Heatran	Machine
Gigalith	Machine
Trubbish	Machine
Garbodor	Machine
Vanillite	Machine
Vanillish	Machine
Vanilluxe	Machine
Cryogonal	Machine
Golett	Machine
Golurk	Machine
Landorus	Machine
Volcanion	Machine
Silvally	Machine
Celesteela	Machine
Magearna	Machine
Blacephalon	Machine
Melmetal	Machine
Rolycoly	Machine
Carkol	Machine
Coalossal	Machine
Polteageist	Machine
Cursola	Machine
Pincurchin	Machine
Stonjourner	Machine
Regieleki	Machine
Regidrago	Machine

Let's Go Pikachu and Let's Go Eevee: 21 species

Species	Method	Level
Geodude	Level up, Machine	19
Graveler	Level up, Machine	19
Golem	Level up, Machine	19
Voltorb	Level up, Machine	19
Electrode	Level up, Machine	19
Koffing	Level up, Machine	24
Weezing	Level up, Machine	24
Grimer	Machine
Muk	Machine
Shellder	Machine
Cloyster	Machine
Gastly	Machine
Haunter	Machine
Gengar	Machine
Onix	Machine
Exeggcute	Machine
Exeggutor	Machine
Snorlax	Machine
Mewtwo	Machine
Mew	Machine
Melmetal	Machine

Ultra Sun and Ultra Moon: 19 species

Species	Method	Level
Forretress	Level up	1, 6
Pineco	Level up	6
Minior	Level up	22
Koffing	Level up	23
Weezing	Level up	23
Geodude	Level up	24
Graveler	Level up	24
Golem	Level up	24
Voltorb	Level up	26
Electrode	Level up	26
Baltoy	Level up	28
Claydol	Level up	28
Ferroseed	Level up	38
Ferrothorn	Level up	38
Genesect	Level up	77
Sudowoodo	Egg
Bonsly	Egg
Munchlax	Egg
Trubbish	Egg

Sun and Moon: 19 species

Species	Method	Level
Forretress	Level up	1, 6
Pineco	Level up	6
Minior	Level up	22
Koffing	Level up	23
Weezing	Level up	23
Geodude	Level up	24
Graveler	Level up	24
Golem	Level up	24
Voltorb	Level up	26
Electrode	Level up	26
Baltoy	Level up	28
Claydol	Level up	28
Ferroseed	Level up	38
Ferrothorn	Level up	38
Genesect	Level up	77
Sudowoodo	Egg
Bonsly	Egg
Munchlax	Egg
Trubbish	Egg

Omega Ruby and Alpha Sapphire: 18 species

Species	Method	Level
Forretress	Level up	1
Pineco	Level up	6
Koffing	Level up	23
Weezing	Level up	23
Geodude	Level up	24
Graveler	Level up	24
Golem	Level up	24
Voltorb	Level up	26
Electrode	Level up	26
Baltoy	Level up	28
Claydol	Level up	28
Ferroseed	Level up	38
Ferrothorn	Level up	38
Genesect	Level up	77
Sudowoodo	Egg
Bonsly	Egg
Munchlax	Egg
Trubbish	Egg

Changed over time

One change since Generation I

1. Through Gen IPower 130200 from Gold and Silver, Generation II