Safeguard is learned by 55 species by level, 259 by machine and 12 by egg

Effect, in PokéAPI's words

“Protects the user’s field from major status ailments and confusion for five turns.”

Who learns it

261 species in all, 3 of 19 games shown

Scarlet and Violet: 31 species

Species	Method	Level
Florges	Level up	1
Arboliva	Level up	1
Moltres	Level up	10
Flabébé	Level up	10
Floette	Level up	10
Lugia	Level up	18
Ho-Oh	Level up	18
Mewtwo	Level up	24
Swablu	Level up	24
Altaria	Level up	24
Bronzor	Level up	24
Bronzong	Level up	24
Finneon	Level up	29
Lumineon	Level up	29
Vivillon	Level up	31
Milotic	Level up	36
Chimecho	Level up	37
Chikorita	Level up	39
Dratini	Level up	40
Vulpix	Level up	44
Alomomola	Level up	45
Dragonair	Level up	46
Dragonite	Level up	46
Bayleef	Level up	46
Cresselia	Level up	48
Luvdisc	Level up	49
Seel	Level up	51
Meganium	Level up	54
Dewgong	Level up	61
Oricorio	Egg
Rabsca	Egg

Brilliant Diamond and Shining Pearl: 127 species

Species	Method	Level
Wobbuffet	Level up, Machine	Evolve, 1
Ninetales	Level up, Machine	1
Wynaut	Level up, Machine	1
Togekiss	Level up, Machine	1
Moltres	Level up, Machine	10
Ledyba	Level up, Machine	12
Ledian	Level up, Machine	12
Lugia	Level up, Machine	18
Ho-Oh	Level up, Machine	18
Shuckle	Level up, Machine	20
Gorebyss	Level up, Machine	23
Mewtwo	Level up, Machine	24
Swablu	Level up, Machine	24
Altaria	Level up, Machine	24
Bronzor	Level up, Machine	24
Bronzong	Level up, Machine	24
Butterfree	Level up, Machine	28
Finneon	Level up, Machine	29
Lumineon	Level up, Machine	29
Mr. Mime	Level up, Machine	36
Togepi	Level up, Machine	36
Togetic	Level up, Machine	36
Milotic	Level up, Machine	36
Mime Jr.	Level up, Machine	36
Chimecho	Level up, Machine	37
Chikorita	Level up, Machine	39
Dratini	Level up, Machine	40
Vulpix	Level up, Machine	44
Dragonair	Level up, Machine	46
Dragonite	Level up, Machine	46
Bayleef	Level up, Machine	46
Cresselia	Level up, Machine	48
Luvdisc	Level up, Machine	49
Seel	Level up, Machine	51
Meganium	Level up, Machine	54
Dewgong	Level up, Machine	61
Bulbasaur	Machine
Ivysaur	Machine
Venusaur	Machine
Raichu	Machine
Sandshrew	Machine
Sandslash	Machine
Clefairy	Machine
Clefable	Machine
Jigglypuff	Machine
Wigglytuff	Machine
Vileplume	Machine
Growlithe	Machine
Arcanine	Machine
Abra	Machine
Kadabra	Machine
Alakazam	Machine
Tentacool	Machine
Tentacruel	Machine
Slowpoke	Machine
Slowbro	Machine
Drowzee	Machine
Hypno	Machine
Chansey	Machine
Kangaskhan	Machine
Scyther	Machine
Lapras	Machine
Mew	Machine
Cleffa	Machine
Igglybuff	Machine
Mareep	Machine
Flaaffy	Machine
Ampharos	Machine
Bellossom	Machine
Sunkern	Machine
Sunflora	Machine
Wooper	Machine
Quagsire	Machine
Slowking	Machine
Scizor	Machine
Corsola	Machine
Blissey	Machine
Celebi	Machine
Treecko	Machine
Grovyle	Machine
Sceptile	Machine
Beautifly	Machine
Ralts	Machine
Kirlia	Machine
Gardevoir	Machine
Shroomish	Machine
Breloom	Machine
Skitty	Machine
Delcatty	Machine
Spinda	Machine
Lunatone	Machine
Solrock	Machine
Baltoy	Machine
Claydol	Machine
Tropius	Machine
Snorunt	Machine
Glalie	Machine
Relicanth	Machine
Regirock	Machine
Regice	Machine
Registeel	Machine
Latias	Machine
Latios	Machine
Kyogre	Machine
Groudon	Machine
Jirachi	Machine
Turtwig	Machine
Grotle	Machine
Torterra	Machine
Wormadam	Machine
Mothim	Machine
Cherubi	Machine
Cherrim	Machine
Chingling	Machine
Happiny	Machine
Snover	Machine
Abomasnow	Machine
Gallade	Machine
Froslass	Machine
Uxie	Machine
Mesprit	Machine
Azelf	Machine
Dialga	Machine
Palkia	Machine
Regigigas	Machine
Giratina	Machine
Manaphy	Machine

Sword and Shield: 201 species

Species	Method	Level
Wobbuffet	Level up, Machine	Evolve, 1
Ninetales	Level up, Machine	1
Wynaut	Level up, Machine	1
Togekiss	Level up, Machine	1
Mr. Rime	Level up, Machine	1
Moltres	Level up, Machine	10
Pyukumuku	Level up, Machine	15
Lugia	Level up, Machine	18
Ho-Oh	Level up, Machine	18
Shuckle	Level up, Machine	20
Drampa	Level up, Machine	20
Mewtwo	Level up, Machine	24
Swablu	Level up, Machine	24
Altaria	Level up, Machine	24
Bronzor	Level up, Machine	24
Bronzong	Level up, Machine	24
Zygarde	Level up, Machine	24
Butterfree	Level up, Machine	28
Mr. Mime	Level up, Machine	36
Togepi	Level up, Machine	36
Togetic	Level up, Machine	36
Milotic	Level up, Machine	36
Mime Jr.	Level up, Machine	36
Dratini	Level up, Machine	40
Vulpix	Level up, Machine	44
Dragonair	Level up, Machine	46
Dragonite	Level up, Machine	46
Cresselia	Level up, Machine	48
Bulbasaur	Machine
Ivysaur	Machine
Venusaur	Machine
Raichu	Machine
Sandshrew	Machine
Sandslash	Machine
Clefairy	Machine
Clefable	Machine
Jigglypuff	Machine
Wigglytuff	Machine
Vileplume	Machine
Growlithe	Machine
Arcanine	Machine
Abra	Machine
Kadabra	Machine
Alakazam	Machine
Tentacool	Machine
Tentacruel	Machine
Slowpoke	Machine
Slowbro	Machine
Chansey	Machine
Kangaskhan	Machine
Scyther	Machine
Lapras	Machine
Mew	Machine
Cleffa	Machine
Igglybuff	Machine
Bellossom	Machine
Wooper	Machine
Quagsire	Machine
Slowking	Machine
Scizor	Machine
Corsola	Machine
Blissey	Machine
Celebi	Machine
Treecko	Machine
Grovyle	Machine
Sceptile	Machine
Ralts	Machine
Kirlia	Machine
Gardevoir	Machine
Lunatone	Machine
Solrock	Machine
Baltoy	Machine
Claydol	Machine
Snorunt	Machine
Glalie	Machine
Relicanth	Machine
Regirock	Machine
Regice	Machine
Registeel	Machine
Latias	Machine
Latios	Machine
Kyogre	Machine
Groudon	Machine
Jirachi	Machine
Cherubi	Machine
Cherrim	Machine
Happiny	Machine
Snover	Machine
Abomasnow	Machine
Gallade	Machine
Froslass	Machine
Uxie	Machine
Mesprit	Machine
Azelf	Machine
Dialga	Machine
Palkia	Machine
Regigigas	Machine
Giratina	Machine
Victini	Machine
Munna	Machine
Musharna	Machine
Woobat	Machine
Swoobat	Machine
Audino	Machine
Cottonee	Machine
Whimsicott	Machine
Petilil	Machine
Lilligant	Machine
Maractus	Machine
Sigilyph	Machine
Yamask	Machine
Cofagrigus	Machine
Minccino	Machine
Cinccino	Machine
Gothita	Machine
Gothorita	Machine
Gothitelle	Machine
Solosis	Machine
Duosion	Machine
Reuniclus	Machine
Frillish	Machine
Jellicent	Machine
Elgyem	Machine
Beheeyem	Machine
Litwick	Machine
Lampent	Machine
Chandelure	Machine
Golett	Machine
Golurk	Machine
Larvesta	Machine
Volcarona	Machine
Cobalion	Machine
Terrakion	Machine
Virizion	Machine
Reshiram	Machine
Zekrom	Machine
Kyurem	Machine
Keldeo	Machine
Espurr	Machine
Meowstic	Machine
Swirlix	Machine
Slurpuff	Machine
Binacle	Machine
Barbaracle	Machine
Amaura	Machine
Aurorus	Machine
Sylveon	Machine
Carbink	Machine
Klefki	Machine
Phantump	Machine
Trevenant	Machine
Pumpkaboo	Machine
Gourgeist	Machine
Bergmite	Machine
Avalugg	Machine
Diancie	Machine
Rowlet	Machine
Dartrix	Machine
Decidueye	Machine
Cutiefly	Machine
Ribombee	Machine
Mareanie	Machine
Toxapex	Machine
Araquanid	Machine
Fomantis	Machine
Lurantis	Machine
Morelull	Machine
Shiinotic	Machine
Bounsweet	Machine
Steenee	Machine
Tsareena	Machine
Comfey	Machine
Oranguru	Machine
Mimikyu	Machine
Jangmo-o	Machine
Hakamo-o	Machine
Kommo-o	Machine
Tapu Koko	Machine
Tapu Lele	Machine
Tapu Bulu	Machine
Tapu Fini	Machine
Solgaleo	Machine
Lunala	Machine
Nihilego	Machine
Stakataka	Machine
Sobble	Machine
Drizzile	Machine
Inteleon	Machine
Dottler	Machine
Orbeetle	Machine
Appletun	Machine
Hatenna	Machine
Hattrem	Machine
Hatterene	Machine
Cursola	Machine
Runerigus	Machine
Alcremie	Machine
Frosmoth	Machine
Stonjourner	Machine
Zamazenta	Machine
Calyrex	Machine